Estrace and its generic: Estradiol

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    Estrace (vaginal estrogen creme) has been great! However, it costs $330.00 for about a month’s use. 45 grams, at a dosage of 2 grams each use, twice a week, sometimes three times a week. I looked for a generic. Found Estradiol, which is available through some online pharmacy companies, including: See: Daynight drugs seems legit, with someone answering my written questions by email.

    Question: has anyone here used Estradiol? And / or this internet pharmacy?

    Estradiol, the generic, costs so much less. About one-tenth of the cost of Estrace. It is delivered in a concentrated form, because the Estradiol is one-tenth the strength of the active ingredient in Estrace. Even at the concentrated level, it costs a fraction of what Estrace costs. Before I ask my doctor for a prescription, I wanted to put the question out here. Thanks.

    Cost is an issue, but not insurmountable.


    Hi Westtexas. How are you doing? I know we have chatted in other threads and I wanted to know if you ended up switching from Estrace to Estradiol? If so, what are your thoughts? Sending you hugs today!


    I always prefer Estrace, but when cost is an issue, I have switched patients from Estrace to compounded estradiol and have had primarily good results. I would just ensure you are using a certified compounding pharmacy with a good reputation. I have never had experience with the pharmacy mentioned in the post. I have used Innovation Compounding,, and they are a PCAB accredited compounding pharmacy.

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